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Stockholders’ Equity (Tables)
 9 Months Ended
Oct. 03, 2021
Equity [Abstract]  
Schedule of Restricted Stock Activity and Related Information, Restricted Stock
Restricted stock activity was as follows:

Restricted
Stock Units
(RSU)(1)
Performance
Stock Units
(PSU)(2)
Weighted-Average Grant Date Fair Value per Share
Units in thousandsRSUPSU
Outstanding at January 3, 20211,721 — $313.35 — 
Awarded183 424 $464.17 $475.77 
Vested(92)— $274.12 — 
Cancelled(206)(34)$316.92 $475.77 
Outstanding at October 3, 20211,606 390 $332.36 $475.77 
_____________
(1)In connection with the GRAIL acquisition, replacement awards of 59,000 RSUs were awarded to GRAIL employees.
(2)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.
Schedule of Restricted Stock Activity and Related Information, Performance Units
Restricted stock activity was as follows:

Restricted
Stock Units
(RSU)(1)
Performance
Stock Units
(PSU)(2)
Weighted-Average Grant Date Fair Value per Share
Units in thousandsRSUPSU
Outstanding at January 3, 20211,721 — $313.35 — 
Awarded183 424 $464.17 $475.77 
Vested(92)— $274.12 — 
Cancelled(206)(34)$316.92 $475.77 
Outstanding at October 3, 20211,606 390 $332.36 $475.77 
_____________
(1)In connection with the GRAIL acquisition, replacement awards of 59,000 RSUs were awarded to GRAIL employees.
(2)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.
Schedule of Stock Option Activity Under all Stock Option Plans
Stock option activity was as follows:

Units in thousandsOptionsWeighted-Average
Exercise Price
Performance Stock Options(1)
Weighted-Average
Exercise Price
Outstanding at January 3, 202110 $59.11 — — 
Granted— — 48 $86.73 
Exercised(2)$20.06 (1)$83.02 
Outstanding at October 3, 20218 $65.58 47 $86.89 
_____________
(1)In connection with the GRAIL acquisition, we issued performance stock options. The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.
Schedule of Share-based Compensation Expense for all Stock Awards
Share-based compensation expense reported in our condensed consolidated statements of income was as follows:

 In millionsQ3 2021Q3 2020YTD 2021YTD 2020
Cost of product revenue$7 $6 $22 $13 
Cost of service and other revenue1 1 3 3 
Research and development193 21 243 48 
Selling, general and administrative496 33 576 52 
Share-based compensation expense before taxes697 61 844 116 
Related income tax benefits(29)(12)(57)(27)
Share-based compensation expense, net of taxes$668 $49 $787 $89 
Schedule of Assumptions used to Estimate the Weighted-Average Fair Value Per Share for Stock Purchase under the Employee Stock Purchase Plan
The assumptions used for the specified reporting periods and the resulting estimates of weighted-average fair value per share for stock purchased under the ESPP during YTD 2021 were as follows:

Employee Stock Purchase Rights
Risk-free interest rate
0.06% - 0.12%
Expected volatility
37% - 47%
Expected term
0.5 - 1.0 year
Expected dividends0 %
Weighted-average grant-date fair value per share$134.47