Revenue - Summary of Disaggregated Revenue (Details) - USD ($) $ in Millions	12 Months Ended
	Jan. 03, 2021	Dec. 29, 2019	Dec. 30, 2018
Revenue from External Customer [Line Items]
Revenue	$ 3,239	$ 3,543	$ 3,333
Americas
Revenue from External Customer [Line Items]
Revenue	1,744	1,970	1,864
Europe, Middle East, and Africa
Revenue from External Customer [Line Items]
Revenue	886	933	851
Greater China
Revenue from External Customer [Line Items]
Revenue	342	372	365
Asia-Pacific
Revenue from External Customer [Line Items]
Revenue	267	268	253
United States
Revenue from External Customer [Line Items]
Revenue	1,655	1,859	1,779
Total product revenue
Revenue from External Customer [Line Items]
Revenue	2,735	2,929	2,749
Consumables
Revenue from External Customer [Line Items]
Revenue	2,304	2,392	2,177
Instruments
Revenue from External Customer [Line Items]
Revenue	431	537	572
Service and other revenue
Revenue from External Customer [Line Items]
Revenue	504	614	584
Sequencing
Revenue from External Customer [Line Items]
Revenue	2,879	3,068	2,775
Sequencing | Total product revenue
Revenue from External Customer [Line Items]
Revenue	2,456	2,592	2,359
Sequencing | Consumables
Revenue from External Customer [Line Items]
Revenue	2,039	2,075	1,824
Sequencing | Instruments
Revenue from External Customer [Line Items]
Revenue	417	517	535
Sequencing | Service and other revenue
Revenue from External Customer [Line Items]
Revenue	423	476	416
Microarray
Revenue from External Customer [Line Items]
Revenue	360	475	558
Microarray | Total product revenue
Revenue from External Customer [Line Items]
Revenue	279	337	390
Microarray | Consumables
Revenue from External Customer [Line Items]
Revenue	265	317	353
Microarray | Instruments
Revenue from External Customer [Line Items]
Revenue	14	20	37
Microarray | Service and other revenue
Revenue from External Customer [Line Items]
Revenue	$ 81	$ 138	$ 168