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Segments and Geographic Data (Tables)
 12 Months Ended
Jan. 03, 2021
Segment Reporting [Abstract]  
Schedule of Operating Performance and Assets by Segment
 In millions202020192018
Revenue:
Core Illumina$3,239 $3,543 $3,334 
Helix— 1 10 
Eliminations— (1)(11)
Consolidated revenue$3,239 $3,543 $3,333 
Depreciation and amortization:
Core Illumina$187 $186 $175 
Helix— 3 6 
Eliminations — (1)(2)
Consolidated depreciation and amortization$187 $188 $179 
Income (loss) from operations:
Core Illumina$580 $1,008 $970 
Helix— (24)(90)
Eliminations— 1 3 
Consolidated income from operations$580 $985 $883 
In millionsJanuary 3,
2021		December 29,
2019		December 30,
2018
Total assets:
Core Illumina$7,585 $7,316 $6,912 
Helix— — 154 
Eliminations— — (107)
Consolidated total assets$7,585 $7,316 $6,959 
Capital expenditures:
Core Illumina$189 $209 $294 
Helix— — 2 
Consolidated capital expenditures$189 $209 $296 
Schedule of Net Long-lived Assets Consisting of Property and Equipment by Region
Net long-lived assets, consisting of property and equipment, by region was as follows:
In millionsJanuary 3,
2021		December 29,
2019
United States$725 $696 
Singapore113 112 
United Kingdom65 62 
Other countries19 19 
Total$922 $889