POWER OF ATTORNEY
KNOW ALL MEN BY THESE PRESENTS, that the undersigned hereby
constitutes and appoints Penny Tom and Octavio Espinoza,
and each of them, his or her true and lawful attorney-in-fact to:
(1)	execute for and on behalf of the undersigned,
in the undersigneds capacity as an officer and/or director
of Illumina, Inc. (the Company), any and all
Form 3, 4 and 5 reports required to be filed by the
undersigned in accordance with Section 16(a) of the
Securities Exchange Act of 1934 and the rules thereunder;
(2)	do and perform any and all acts for and on behalf
of the undersigned which may be necessary or desirable to
complete and execute any such Form 3, 4 or 5 report and timely
file such report with the United States Securities and Exchange
Commission and any stock exchange or similar authority; and
(3)	take any other action of any type whatsoever in
connection with the foregoing which, in the opinion of such
attorney in-fact, may be of benefit to, in the best interest of,
or legally required by, the undersigned, it being understood
that the documents executed by such attorney in-fact on behalf
of the undersigned, pursuant to this Power of Attorney, shall be
in such form and shall contain such terms and conditions as such
attorney in-fact may approve in his discretion.
The undersigned hereby grants to each such attorney-in-fact
full power and authority to do and perform each and every act
and thing whatsoever requisite, necessary, and proper to be
done in the exercise of any of the rights and powers herein
granted, as fully to all intents and purposes as the undersigned
might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming
all that such attorney-in-fact, or his or her substitute or
substitutes, shall lawfully do or cause to be done by virtue of
this Power of Attorney and the rights and powers herein granted.
The undersigned acknowledges that no such attorney in-fact,
in serving in such capacity at the request of the undersigned,
is hereby assuming, nor is the Company hereby assuming, any of
the undersigneds responsibilities to comply with
Section 16 of the Securities Exchange Act of 1934.
This Power of Attorney shall remain in full force and
effect until the undersigned is no longer required to file
Form 3, 4 and 5 reports with respect to the undersigneds
holdings of and transactions in securities issued by the
Company, unless earlier revoked by the undersigned in a
signed writing delivered to the foregoing attorneys in-fact.

IN WITNESS WHEREOF, the undersigned has caused this
Power of Attorney to be executed as of this 10th day of
April, 2008.


/s/Tristan B. Orpin
[Signature]
Tristan B. Orpin
[Name]