X0306 4 2016-09-26 0 0001643848 Patheon N.V. PTHN 0001110176 LEVY PAUL S C/O PATHEON N.V. HERENGRACHT 483 AMSTERDAM P7 1017 BT NETHERLANDS 1 0 0 0 Ordinary Shares 2016-09-26 4 P 0 5000 29.65 A 42000 I By Great Point Ventures, LLC Ordinary Shares 2016-09-27 4 P 0 5000 29.65 A 47000 I By Great Point Ventures, LLC Ordinary Shares 2016-09-28 4 P 0 5000 29.61 A 52000 I By Great Point Ventures, LLC The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $29.47 to $29.87, inclusive. The reporting person undertakes to provide to Patheon N.V., any security holder of Patheon N.V., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote (1) to this Form 4. These shares are held by Great Point Ventures, LLC ("GPV"). The reporting person is the sole manager of GPV, the members of which are certain trusts held for the benefit of family members of the reporting person. The reporting person disclaims beneficial ownership of the securities held by GPV, except to the extent of his pecuniary interest, if any, in the securities by virtue of his ownership of GPV. This report shall not be deemed an admission that the reporting person is the beneficial owner of such securities. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $29.40 to $29.95, inclusive. The reporting person undertakes to provide to Patheon N.V., any security holder of Patheon N.V., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote (3) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $29.55 to $29.65, inclusive. The reporting person undertakes to provide to Patheon N.V., any security holder of Patheon N.V., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote (4) to this Form 4. /s/ Eric Sherbet, as attorney-in-fact 2016-09-28