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Stock-based Activity (Details Narrative) - USD ($)
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Dec. 31, 2015
Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Unrecognized stock-based compensation expense, options $ 3,331,388   $ 3,331,388   $ 384,326,400  
Unrecognized stock-based compensation expense, recognition period         2 years 3 months 7 days  
Weighted average remaining Contractual term, stock options outstanding     9 years   9 years 1 month 17 days 7 years 10 months 24 days
Options Granted     223,716 353,493 407,547 12,280
Weighted average exercise price     $ 5.40   $ 16.50 $ 62.68
Volatility minimum 81.98% 86.62% 81.98% 86.62%    
Volatility maximum 83.75%   83.75%      
Dividend rate 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
Expected term 6 years 6 years 6 years 6 years    
Risk-free interest rate, minimum 1.23% 0.87% 1.23% 0.87%    
Risk-free interest rate, maximum 1.43%   1.43%      
Restricted Stock [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Weighted average remaining Contractual term, stock options outstanding     1 year 9 months 18 days      
Options Granted     294,709      
Restricted Stock [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Unrecognized stock-based compensation expense, options $ 2,975,469   $ 2,975,469