Stock-based Activity (Tables)

9 Months Ended

Sep. 30, 2015

Stock-based Activity Tables

Stock-based Compensation

	Three Months Ended		Three Months Ended		Nine Months Ended		Nine Months Ended
	September 30,		September 30,		September 30,		September 30,
	2015		2014		2015		2014
Research and development	$	307,892	$	32,082	$	633,593	$	109,509
General and administrative		1,186,931		111,650		2,333,010		401,090
Total share-based compensation expense	$	1,494,823	$	143,732	$	2,966,603	$	510,599

Stock-based Award Activity

	Options Outstanding			Weighted-Average Exercise Price
Outstanding at December 31, 2014		242,893		$	3.92
Granted		3,015,850			2.23
Exercised		(2,779	)		0.29
Forfeited/cancelled/expired		(12,923	)		7.42
Outstanding and expected to vest at September 30, 2015		3,243,041		$	2.36
Vested and exercisable at September 30, 2015		170,063		$	3.60

Restricted stock grants

	Shares		Weighted-Average Grant-Date Fair Value
Nonvested at December 31, 2014		—	$	—
Granted		2,300,850		2.28
Vested		—		—
Forfeited		—		—
Nonvested at September 30, 2015		2,300,850	$	2.28

Common stock reserved for future issuance

Common stock reserved for conversion of preferred stock	22,482,400
Common stock reserved for exercise of warrants	5,959,668
Common stock options outstanding	3,243,041
Unvested restricted stock awards	2,300,850
Authorized for future grant or issuance under the Stock Plan	2,970,012
Total	36,955,971