CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities:
Net loss	$ (45,343)	$ (31,816)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	141	120
Non-cash lease expense	840	616
Stock-based compensation expense	5,008	3,838
Non-cash imputed interest expense related to the sale of future royalties	28	9
Net amortization of premiums and discounts on marketable securities	651	1,013
Gain on forgiveness of PPP Loan	0	(890)
Changes in operating assets and liabilities:
Accounts receivable	338	84
Prepaid expenses and other current assets	(875)	(1,870)
Other assets	(2,022)	0
Accounts payable and accrued and other liabilities	(187)	1,025
Operating lease liability	(648)	(1,577)
Total adjustments	3,274	2,368
Net cash used in operating activities	(42,069)	(29,448)
Cash flows from investing activities:
Purchase of investments	(49,419)	(70,977)
Sales and maturities of investments	79,395	26,605
Purchase of property and equipment	(416)	0
Net cash provided by (used in) investing activities	29,560	(44,372)
Cash flows from financing activities:
Proceeds from issuance of common stock associated with 2021 Sales Agreement, net of issuance costs	5,663	0
Proceeds from issuance of common stock under the Company's share-based compensation plan	149	217
Payment of liability of future royalties, net of imputed interest	(3,557)	(3,077)
Net cash provided by (used in) financing activities	2,255	(2,860)
Net decrease in cash and cash equivalents and restricted cash	(10,254)	(76,680)
Cash and cash equivalents and restricted cash, beginning of period	40,740	130,426
Cash and cash equivalents and restricted cash, end of period	30,486	53,746
Supplemental cash flow data:
Issuance costs in accrued expenses and accounts payable	69	0
Cash paid for interest	3,093	3,357
Decrease in right-of-use assets and operating lease liabilities resulting from lease modification	$ (191)	$ 0