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Stock Plans and Stock-Based Compensation - Summary of ESPP (Details) - Employee Stock Purchase Plan - 2010 Employee Stock Purchase Plan
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Minimum risk-free interest rate (percent) 0.10% 0.10% 1.50%
Maximum risk-free interest rate (percent) 0.50% 0.20% 2.10%
Minimum volatility (percent) 51.00% 97.00% 92.00%
Maximum volatility (percent) 154.00% 219.00% 97.00%
Dividends 0.00% 0.00% 0.00%
Minimum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Expected term 6 months 6 months 6 months
Maximum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Expected term 24 months 24 months 24 months