Liability Related to the Sale of Future Royalties (Details) - USD ($) $ in Thousands		12 Months Ended
	Mar. 31, 2019	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Nonmonetary Transaction [Line Items]
Proceeds from royalty interest purchase agreement with Oberland Capital Management		$ 0	$ 0	$ 65,000
Non-cash interest rate (percent)	7.80%
Transaction fees	$ 600
Nonmonetary Transaction [Roll Forward]
Carrying value of liability related to the sale of future royalties at January 1, 2021		58,235	62,477
Amortization of capitalized issuance costs		61	61
Imputed interest expense recognized for the year ended December 31, 2021		4,411	5,034
Less: payments to Oberland Capital, LLC		(8,909)	(9,337)
Carrying value of liability related to the sale of future royalties at December 31, 2021		$ 53,798	$ 58,235	$ 62,477
Oberland Capital
Nonmonetary Transaction [Line Items]
Proceeds from royalty interest purchase agreement with Oberland Capital Management	65,000
Purchaser default option period (days)		180 days
Aggregate Net Royalties Prior To 2027 | Oberland Capital
Nonmonetary Transaction [Line Items]
Cash proceeds from royalty purchase agreement	53,500
Royalty amount threshold	$ 117,000