Collaborative Arrangement, Number of Programs Licensed

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Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Short-term investments, exclusive of cash equivalents, generally consist of marketable securities intended to be sold within one year (or the normal operating cycle if longer) and may include trading securities, available-for-sale securities, or held-to-maturity securities (if maturing within one year), as applicable.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

Contractual interest rate for funds borrowed, under the debt agreement.

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Amount, after unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations.

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Period between issuance and maturity of long-term debt, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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- Definition

Amount of cash inflow (outflow) from operating activities, including discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities.

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The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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Number of segments reported by the entity. A reportable segment is a component of an entity for which there is an accounting requirement to report separate financial information on that component in the entity's financial statements.

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The cumulative amount of the reporting entity's undistributed earnings or deficit.

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Nature of Business (Details) $ in Thousands	3 Months Ended
Nature of Business (Details) $ in Thousands	Mar. 31, 2020 USD ($) segment	Mar. 31, 2019 USD ($)	Apr. 21, 2020 USD ($)	Dec. 31, 2019 USD ($)	Mar. 31, 2018 program	Oct. 31, 2016 program
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of reportable segments \| segment	1
Retained earnings (accumulated deficit)	$ (1,026,690)			$ (1,016,981)
Net loss	9,709	$ 9,884
Cash used in operations	9,016	$ 7,233
Cash, cash equivalents, and investments	$ 12,500
Aurigene
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of programs licensed in collaboration agreement \| program					4	3
Cares Act PPP Loan \| Subsequent Event \| Commercial Paper \| Silicon Valley Bank
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Unsecured loan			$ 900
Unsecured loan term (months)			24 months
Unsecured loan interest rate (percent)			1.00%