Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Income Taxes [Line Items]
Net operating loss carryforwards	$ 163,254	$ 154,634
Deferred tax assets operating loss carryforwards without expire date	436,000
Research and development credit carryforwards	40,345	40,486
Reduced credits carryforward		0
Uncertain tax positions adjustment	0	$ 0
Increase (decrease) in deferred tax assets	303
Interest and penalties	0
Domestic Tax Authority [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	$ 775,000
Net operating loss carryforwards, expiration date	2037
Federal and State [Member]
Income Taxes [Line Items]
Deferred tax assets operating loss carryforwards with expire date	$ 339,000
Net operating loss carryforwards, expiration date	2045
Federal and State [Member] | Research Tax Credit Carryforward
Income Taxes [Line Items]
Research and development credit carryforwards	$ 40,300
State and Local Jurisdiction [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	498,000
Increase (decrease) in deferred tax assets	0
Florida [Member]
Income Taxes [Line Items]
Gross net operating loss	$ 10,900