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Warrants - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Sep. 12, 2019
Nov. 11, 2018
Sep. 30, 2019
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Number of securities into which the class of warrant converted   18,939,394        
Warrant Exercise Per share   $ 2.64        
Fair Value Assumptions Expected volatility Rate Maximum       85.00% 84.71% 81.03%
Fair Value Assumptions Risk Free Interest Rate Maximum       2.53% 3.06% 2.27%
Fair Value Assumptions Expected Term1       5 years 6 years 6 years
Net Proceeds from Underwriting       $ 6,085 $ 47,101 $ 47,270
Proceeds from private placement $ 52,500          
Non-cash inducement warrant expense     $ (60,751) $ 60,751    
MD Anderson Warrant [Member]            
Number of securities into which the class of warrant converted       3,333,333    
Warrant Exercise Per share       $ 0.001    
Grant Date Fair Value of a warrant       $ 14,500    
Warrant Expiry date       Dec. 31, 2026    
Securities Purchase Agreement [Member]            
Net Proceeds from Underwriting   $ 47,100   $ 47,100    
Private Placement [Member]            
Number of securities into which the class of warrant converted 17,803,031     18,939,394    
Warrant Exercise Per share $ 3.01     $ 3.01    
Grant Date Fair Value of a warrant       $ 18,400    
Fair Value Assumptions Expected volatility Rate Maximum       71.00%    
Fair Value Assumptions Risk Free Interest Rate Maximum       2.99%    
Placement agent fees and other expenses $ 1,100          
Private Placement [Member] | New Warrants [Member]            
Number of securities into which the class of warrant converted 17,803,031          
Warrant Exercise Per share $ 7.00          
Non-cash inducement warrant expense $ 60,800     $ 60,800