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Business - Additional Information (Detail) - USD ($)
$ in Thousands
Sep. 30, 2017
Dec. 31, 2016
Sep. 30, 2016
Dec. 31, 2015
Accounting Policies [Abstract]        
Accumulated deficit $ (699,169) $ (657,997)    
Cash and cash equivalents $ 84,406 $ 81,053 $ 94,683 $ 140,717