STATEMENT OF STOCKHOLDERS' EQUITY (DEFICIT) - 9 months ended Sep. 30, 2016 - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital Common Stock	Accumulated Deficit	Series 1 Preferred Stock
Beginning Balance (in shares) at Dec. 31, 2015		131,718,579
Beginning Balance at Dec. 31, 2015	$ 87,371	$ 132	$ 579,939	$ (492,700)
Stock-based compensation	$ 6,094		6,094
Exercise of employee stock options (in shares)	169,000	137,346
Exercise of employee stock options	$ 551	$ 1	550
Repurchase of common stock (in shares)		(168)
Repurchase of common stock	(2)		(2)
Restricted stock buy-back at vesting to cover taxes (in shares)		(123,334)
Restricted stock buy-back at vesting to cover taxes	(853)	$ (1)	(852)
Issuance of stock in a license agreement	87		87		$ 118,241
Issuance of stock in a license agreement (in shares)					100,000
Issuance of stock in a license agreement	87		87		$ 118,241
Issuance of preferred stock dividends (in shares)					3,063
Issuance of preferred stock dividends	(3,591)		(3,591)		$ 3,571
Net loss	(154,073)			(154,073)
Ending Balance (in shares) at Sep. 30, 2016		131,732,423			103,063
Ending Balance at Sep. 30, 2016	$ (64,416)	$ 132	$ 582,225	$ (646,773)	$ 121,812