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Component of Accrued Expenses (Detail) (USD $)
In Thousands, unless otherwise specified
Dec. 31, 2013
Dec. 31, 2012
Accrued Liabilities [Line Items]    
Professional services $ 582 $ 835
Clinical consulting services 3,751 9,628
Preclinical services 513 411
Manufacturing services 547 3,217
Accrued vacation 227 452
Other consulting services 230 903
Payroll taxes and benefits 255 585
Severance   474
Employee compensation 252 11
Accrued expenses $ 6,357 $ 16,516