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Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Antidilutive securities excluded from computation of earnings per share, amount 19,078,496 19,206,656 20,827,830
Stock Option
     
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Antidilutive securities excluded from computation of earnings per share, amount 7,147,303 5,138,486 4,566,935
Unvested Restricted Common Stock
     
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Antidilutive securities excluded from computation of earnings per share, amount 733,739 950,906 348,753
Warrant Exercise
     
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Antidilutive securities excluded from computation of earnings per share, amount 11,197,454 13,117,264 15,912,142