POWER OF ATTORNEY

	For Executing Forms 3, 4 and 5

        Know all by these presents, that the undersigned hereby constitutes and
appoints Jonathan Lewis and Richard E. Bagley, signing individually, his true
and lawful attorneys-in-fact to:

1.	Execute for and on behalf of the undersigned Initial Statements of
Beneficial Ownership of Securities on Form 3, Statements of Changes of
Beneficial Ownership of Securities on Form 4 and Annual Statements of
Beneficial Ownership of Securities on Form 5, for the purpose of reporting
transactions by the undersigned in securities issued by Ziopharm Oncology, Inc.
in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the
rules thereunder;

2.	Do and perform any and all acts for and on behalf of the undersigned
which may be necessary or desirable to complete the execution of any such
Form 3, 4 or 5 and the timely filing thereof with the United States Securities
and Exchange Commission and any other applicable governmental or regulatory
authority; and

3.	Take any other action of any type whatsoever in connection with the
foregoing which in the opinion of such attorney-in-fact, may be of benefit to,
in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf of
the undersigned pursuant to this Power of Attorney shall be in such form and
shall contain such terms and conditions as such attorney-in-fact may approve
in his discretion.

        The undersigned hereby grants to each such attorney-in-fact full power
and authority to do and perform all and every act and thing whatsoever
requisite, necessary and proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as such
attorney-in-fact might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that such
attorney-in-fact, or his substitute or substitutes, shall lawfully do or cause
to be done by virtue of this power of attorney and the rights and powers herein
granted.  The undersigned acknowledges that the foregoing attorneys-in-fact, in
serving in such capacity at the request of the undersigned, are not assuming
any of the undersigned's responsibilities to comply with Section 16 of the
Securities Exchange Act of 1934.

        This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4 and 5 with respect to the
undersigned's holdings of and transactions in securities issued by Ziopharm
Oncology, Inc., unless earlier revoked by the undersigned in a signed writing
delivered to the foregoing attorneys-in-fact.

        IN WITNESS WHEREOF, the undersigned has executed this Power of
Attorney as of this  25th  day of June, 2009.

			/s/ Gary S. Fragin
			(signature)

			_Gary S. Fragin __
    			(print name)