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Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail)
9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive securities excluded from computation of earnings per share, amount 17,481,779 18,460,035
Stock Option [Member]
   
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive securities excluded from computation of earnings per share, amount 5,361,487 4,981,398
Unvested Restricted Common Stock [Member]
   
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive securities excluded from computation of earnings per share, amount 922,838 298,752
Warrant Exercise [Member]
   
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive securities excluded from computation of earnings per share, amount 11,197,454 13,179,885