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Potential Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail)
6 Months Ended
Jun. 30, 2012
Jun. 30, 2011
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive securities excluded from computation of earnings per share, amount 17,695,680 18,291,650
Stock Option
   
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive securities excluded from computation of earnings per share, amount 5,397,154 4,790,552
Unvested restricted common stock
   
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive securities excluded from computation of earnings per share, amount 1,029,848 248,752
Warrant Exercise
   
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive securities excluded from computation of earnings per share, amount 11,268,678 13,252,346