Exhibit 12.1

ZIOPHARM Oncology, Inc.

Computation of Ratio of Earnings to Fixed Charges

	Fiscal Year Ended December 31,															Three Months Ended March 31,
$ In Thousands, Except Ratio	2005			2006			2007			2008			2009			2010
Fixed charges:
Interest Expense	$	-		$	-		$	-		$	-		$	-		$	-
Amortized premiums discounts and capitalized expenses related to indebtedness		-			-			-			-			-			-
	$	-		$	-		$	-		$	-		$	-		$	-
Earnings (loss):
Net income (loss) before tax benefit (provision)	$	(9,517	)	$	(17,857	)	$	(26,608	)	$	(25,231	)	$	(7,649	)	$	(17,653	)
Add fixed charges		-			-			-			-			-			-
	$	(9,517	)	$	(17,857	)	$	(26,608	)	$	(25,231	)	$	(7,649	)	$	(17,653	)
Ratio of earnings to fixed charges		-			-			-			-			-			-
Deficiency of earnings to fixed charges	$	(9,517	)	$	(17,857	)	$	(26,608	)	$	(25,231	)	$	(7,649	)	$	(17,653	)