Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Income Taxes [Line Items]
Net operating loss carryforwards	$ 154,634	$ 148,009
Deferred tax assets operating loss carryforwards without expire date	395,000
Research and development credit carryforwards	40,486	39,838
Reduced credits carryforward	0
Uncertain tax positions adjustment	0	$ 0
Increase (decrease) in deferred tax assets	2,250
Interest and penalties	0
Domestic Tax Authority [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	$ 737,000
Net operating loss carryforwards, expiration date	2037
Federal and State [Member]
Income Taxes [Line Items]
Deferred tax assets operating loss carryforwards with expire date	$ 342,000
Net operating loss carryforwards, expiration date	2043
Federal and State [Member] | Research Tax Credit Carryforward
Income Taxes [Line Items]
Research and development credit carryforwards	$ 40,500
State and Local Jurisdiction [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	498,000
Increase (decrease) in deferred tax assets	$ 0