Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Taxes [Line Items]
Net operating loss carryforwards	$ 171,070	$ 164,486
Deferred tax assets operating loss carryforwards without expire date	323,800
Research and development credit carryforwards	40,116	39,817
Uncertain Tax Positions Adjustment	0	$ 0
Increase (decrease) in deferred tax assets	6,700
Domestic Tax Authority [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	$ 665,500
Net operating loss carryforwards, expiration date	2037
Federal and State [Member]
Income Taxes [Line Items]
Deferred tax assets operating loss carryforwards with expire date	$ 341,700
Net operating loss carryforwards, expiration date	2042
Federal and State [Member] | Research Tax Credit Carryforward
Income Taxes [Line Items]
Research and development credit carryforwards	$ 40,100
State and Local Jurisdiction [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	$ 497,900