Restructuring - Future termination benefit payments resulting from the strategic reduction in force (Detail) $ in Thousands	12 Months Ended
Dec. 31, 2021 USD ($)
Restructuring Cost and Reserve [Line Items]
Severance Costs	$ 3,657
Research and Development [Member]
Restructuring Cost and Reserve [Line Items]
Severance Costs	2,368
General and Administrative [Member]
Restructuring Cost and Reserve [Line Items]
Severance Costs	$ 1,289

Amount of expenses for special or contractual termination benefits provided to current employees involuntarily terminated under a benefit arrangement associated exit or disposal activities pursuant to an authorized plan. Excludes expenses related to one-time termination benefits, a discontinued operation or an asset retirement obligation.

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3602-108585

Name:	us-gaap_SeveranceCosts1
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration