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Warrants - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 28, 2021
Aug. 06, 2021
Oct. 22, 2019
Sep. 12, 2019
Nov. 11, 2018
Dec. 31, 2022
Dec. 31, 2021
Fair Value Assumptions Expected volatility Rate Maximum           88.75% 74.80%
Fair Value Assumptions Risk Free Interest Rate Maximum           4.21% 1.36%
Aggregate offering price           $ 14,724  
Proceeds from private placement       $ 52,500      
Silicon Valley Bank Loan [Member]              
Warrant Exercise Per share $ 1.16 $ 2.22          
Number of warrants issued   432,844          
MD Anderson Warrant [Member]              
Number of securities into which the class of warrant converted     3,333,333        
Warrant Exercise Per share     $ 0.001        
Fair Value of Warrants     $ 14,500        
Warrant Expiry date     Dec. 31, 2026        
Svb Warrants [Member]              
Common stock   432,844          
Exercise price   2.22          
Warrants fully vested upon issuance   10 years          
Black-Scholes Model [Member] | Silicon Valley Bank Loan [Member]              
Fair Value Assumptions Expected Term1 10 years            
Exercise price 1.16            
Expected volatility 81.00%            
Risk-free interest rate 1.49%            
Number of warrants issued 649,615            
Dividends $ 0            
Fair Value, Liability, Recurring Basis, Unobservable Input Reconciliation, Gain (Loss), Statement of Income or Comprehensive Income [Extensible Enumeration]             Other Nonoperating Income (Expense)
Change in fair value             $ 200
Black-Scholes Model [Member] | Svb Warrants [Member]              
Fair Value of Warrants   $ 800          
Fair Value Assumptions Expected Term1   10 years          
Expected volatility   79.00%          
Risk-free interest rate   1.31%          
Dividends   $ 0          
Securities Purchase Agreement [Member]              
Aggregate offering price         $ 47,100    
Private Placement [Member]              
Number of securities into which the class of warrant converted       17,803,031 18,939,394    
Warrant Exercise Per share       $ 3.01 $ 3.01    
Fair Value Assumptions Expected volatility Rate Maximum         71.00%    
Fair Value Assumptions Risk Free Interest Rate Maximum         2.99%    
Fair Value Assumptions Expected Term1         5 years    
Placement agent fees and other expenses       $ 1,100      
Fair value of adjustment of warrants         $ 18,400    
Dividends         $ 0    
Private Placement [Member] | New Warrants [Member]              
Number of securities into which the class of warrant converted       17,803,031      
Warrant Exercise Per share       $ 7.00      
Non-cash inducement warrant expense       $ 60,800