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Stock-Based Compensation - Stock Option Activity Under Stock Option Plan (Details) - $ / shares
3 Months Ended 12 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Number of Shares      
Beginning Balance 10,665,869    
Granted 2,690,000 4,314,438  
Cancelled (2,386,216)    
Ending Balance 10,969,653   10,665,869
Options exercisable, at end of period 3,394,055   4,410,312
Options available for future grant 15,242,103    
Weighted Average Exercise Price      
Beginning Balance $ 2.87    
Granted 0.69    
Cancelled 3.68    
Ending Balance 2.16   $ 2.87
Options exercisable, at end of period $ 3.35   $ 3.85
Weighted Average Contractual Term (Years)      
Outstanding, at end of period 9 years 7 days    
Options exercisable, at end of period 7 years 10 months 9 days   7 years 6 months 10 days