Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Summary Of Significant Accounting Policies [Line Items]
Stock based compensation expenses	$ 10,774	$ 6,829
Weighted average fair value of stock option granted	$ 2.62	$ 2.15
Asset Impairment Charges	$ 740	$ 0
Operating Lease Impairment Loss	600
Collaboration revenue	398	0
Accumulated deficit	$ (842,852)	(764,101)
Office and computer equipment
Summary Of Significant Accounting Policies [Line Items]
Property and equipment useful life	3 years
Software
Summary Of Significant Accounting Policies [Line Items]
Property and equipment useful life	3 years
Laboratory equipment
Summary Of Significant Accounting Policies [Line Items]
Property and equipment useful life	5 years
Leasehold improvements
Summary Of Significant Accounting Policies [Line Items]
Asset Impairment Charges	$ 100
Estimated useful life	Life of the lease
Stock Options
Summary Of Significant Accounting Policies [Line Items]
Stock based compensation expenses	$ 7,400	4,300
Restricted Stock
Summary Of Significant Accounting Policies [Line Items]
Stock based compensation expenses	3,400	2,500
Restricted Stock Units (RSUs) [Member]
Summary Of Significant Accounting Policies [Line Items]
Stock based compensation expenses	$ 10,800	$ 6,800