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  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0001107414</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000010695</seriesId>
        <classId>C000029583</classId>
        <classId>C000136665</classId>
        <classId>C000136666</classId>
        <classId>C000029582</classId>
        <classId>C000029581</classId>
        <classId>C000136667</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
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    <genInfo>
      <regName>STATE STREET INSTITUTIONAL INVESTMENT TRUST</regName>
      <regFileNumber>811-09819</regFileNumber>
      <regCik>0001107414</regCik>
      <regLei>549300P1E098W6ES7M39</regLei>
      <regStreet1>One Iron Street</regStreet1>
      <regCity>Boston</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02210</regZipOrPostalCode>
      <regPhone>617-664-7037</regPhone>
      <seriesName>State Street Equity 500 Index Fund</seriesName>
      <seriesId>S000010695</seriesId>
      <seriesLei>549300H1RTP6FLZEZA60</seriesLei>
      <repPdEnd>2021-12-31</repPdEnd>
      <repPdDate>2021-12-31</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>3362812504.23</totAssets>
      <totLiabs>538752.80</totLiabs>
      <netAssets>3362273751.43</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>0.00000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>0.00000000</cshNotRptdInCorD>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000029583" rtn1="6.95000000" rtn2="-0.74000000" rtn3="4.40000000"/>
          <monthlyTotReturn classId="C000136665" rtn1="1.34000000" rtn2="-5.94000000" rtn3="-1.07000000"/>
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          <monthlyTotReturn classId="C000029581" rtn1="6.98000000" rtn2="-0.70000000" rtn3="4.44000000"/>
          <monthlyTotReturn classId="C000136667" rtn1="6.98000000" rtn2="-0.71000000" rtn3="4.43000000"/>
        </monthlyTotReturns>
        <othMon1 netRealizedGain="-285350.06000000" netUnrealizedAppr="201815873.81000000"/>
        <othMon2 netRealizedGain="91418.20000000" netUnrealizedAppr="-23407737.02000000"/>
        <othMon3 netRealizedGain="-109036.19000000" netUnrealizedAppr="61768797.82000000"/>
      </returnInfo>
      <mon1Flow redemption="68142793.91000000" reinvestment="0.00000000" sales="41727692.23000000"/>
      <mon2Flow redemption="31753986.29000000" reinvestment="0.00000000" sales="145685657.43000000"/>
      <mon3Flow redemption="64175469.63000000" reinvestment="88767584.52000000" sales="116592360.47000000"/>


    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>State Street Equity 500 Index II Portfolio</name>
        <lei>549300IDK82VZN2AFK60</lei>
        <title>State Street Equity 500 Index II Portfolio</title>
        <cusip>85749T756</cusip>
        <identifiers>
          <isin value="US85749T7569"/>
        </identifiers>
        <balance>7782569.74800000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3362770562.41000000</valUSD>
        <pctVal>100.0147760419</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2022-01-28</ncom:dateSigned>
      <ncom:nameOfApplicant>STATE STREET INSTITUTIONAL INVESTMENT TRUST</ncom:nameOfApplicant>
      <ncom:signature>Arthur Jensen</ncom:signature>
      <ncom:signerName>Arthur Jensen</ncom:signerName>
      <ncom:title>Deputy Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
