Note 11 - Related Parties (Details Textual) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Related Party Transaction, Expenses from Transactions with Related Party	$ 44,924	$ 65,081
Share-based Compensation [Member]
Related Party Transaction, Expenses from Transactions with Related Party	17,431	50,049
Research and Development Expense [Member]
Related Party Transaction, Expenses from Transactions with Related Party	0	0
Reimbursement [Member]
Related Party Transaction, Amounts of Transaction	$ 27,493	$ 15,032