X0303 4 2010-12-30 0001082554 UNITED THERAPEUTICS Corp UTHR 0001106578 ROTHBLATT MARTINE A C/O UNITED THERAPEUTICS CORPORATION 1040 SPRING STREET SILVER SPRING MD 20910 1 1 CEO Common Stock 2010-12-30 2010-12-30 4 M 0 8000 30.75 A 8000 D Common Stock 2010-12-30 2010-12-30 4 S 0 8000 63.644 D 0 D Common Stock 567132 I By Trusts Stock Options 30.75 2010-12-30 2010-12-30 4 M 0 8000 0 D 2009-12-26 2017-12-31 Common Stock 8000 1109214 D Stock Options 63.22 2010-12-31 4 A 0 540861 0 A 2010-12-31 2020-12-31 Common Stock 540861 540861 D Shares held by the reporting person in GRATs and PMTs. Exercise price and number of shares/awards has been adjusted to reflect the issuer's two-for-one stock split on September 22, 2009. This exercise of stock options and corresponding sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person. 2010 stock option award made in accordance with the terms of reporting person's employment agreement, which entitles the reporting person to an annual award of stock options to purchase the number of shares of common stock that is equal to one-eighteenth of one percent of the increase in the issuer's market capitalization from December of the previous year to December of the current year, based on the average closing price of the issuer's common stock during the relevant month. /s/ John S. Hess, Jr. under Power of Attorney 2010-12-31