<?xml version="1.0" encoding="UTF-8"?><!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com --><!-- Created: Thu Oct 15 19:03:10 UTC 2026 --><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:common="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001105806</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>10/13/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0002002988</issuerCik>
        <issuerName>Retension Pharmaceuticals, Inc.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>76135H100</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <common:street1>1104 West Broad Street, #1029</common:street1>
          <common:city>Falls Church</common:city>
          <common:stateOrCountry>VA</common:stateOrCountry>
          <common:zipCode>22046</common:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Laurence W. Lytton</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>617207</soleVotingPower>
        <sharedVotingPower>0</sharedVotingPower>
        <soleDispositivePower>617207</soleDispositivePower>
        <sharedDispositivePower>0</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>617207</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>7.4</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>Percentage calculated based on 8,331,599 shares of Common Stock outstanding following the closing of the Issuer's initial public offering on October 13, 2026, as reported in the Prospectus filed by the Issuer on October 9, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Retension Pharmaceuticals, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>1104 West Broad Street, #1029, Falls Church, VA 22046</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Laurence W. Lytton</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>467 Central Park West
New York, NY 10025</principalBusinessOfficeOrResidenceAddress>
        <citizenship>United States</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>617,207</amountBeneficiallyOwned>
        <classPercent>7.4</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>617,207</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>617,207</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Laurence W. Lytton</reportingPersonName>
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      <signatureDetails>
        <signature>/s/ Laurence W. Lytton</signature>
        <title>Reporting person</title>
        <date>10/15/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
