<?xml version="1.0" encoding="UTF-8"?><!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com --><!-- Created: Mon Aug 17 20:06:57 UTC 2026 --><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:common="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0000935836-26-000393</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001105806</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>4</amendmentNo>
      <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>08/13/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001872529</issuerCik>
        <issuerName>MDxHealth SA</issuerName>
        <issuerCusips>
          <issuerCusipNumber>B5950S113</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <common:street1>CAP BUSINESS CENTER, RUE D'ABHOOZ</common:street1>
          <common:street2>31, B-4040</common:street2>
          <common:city>HERSTAL</common:city>
          <common:stateOrCountry>C9</common:stateOrCountry>
          <common:zipCode>00000</common:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Laurence W. Lytton</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>3933448</soleVotingPower>
        <sharedVotingPower>14625540</sharedVotingPower>
        <soleDispositivePower>3933448</soleDispositivePower>
        <sharedDispositivePower>14625540</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>18558988</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>19.5</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>Percentage calculated based on 95,417,382 Ordinary Shares outstanding as of August 13, 2026, as reported in the Form 6-K filed by the Issuer on August 13, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>Lytton-Kambara Foundation</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>11583098</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>11583098</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>11583098</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>12.1</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>Percentage calculated based on 95,417,382 Ordinary Shares outstanding as of August 13, 2026, as reported in the Form 6-K filed by the Issuer on August 13, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>MDxHealth SA</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>CAP Business Center, Zone Industrielle des Hauts-Sarts, 4040 Herstal, Belgium</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Laurence W. Lytton

Lytton-Kambara Foundation (Foundation)</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>467 Central Park West
New York, NY 10025</principalBusinessOfficeOrResidenceAddress>
        <citizenship>See cover page for each reporting person.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>Lytton:  18,558,988

Foundation:  11,583,098</amountBeneficiallyOwned>
        <classPercent>Lytton:  19.5%

Foundation:  12.1%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>Lytton:  3,933,448

Foundation:  0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>Lytton:  14,625,540

Foundation:  11,583,098</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>Lytton:  3,933,448

Foundation:  0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>Lytton:  14,625,540

Foundation:  11,583,098</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>EXHIBIT 99.1 - AGREEMENT REGARDING JOINT FILING OF STATEMENT ON SCHEDULE 13D OR 13G</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>Laurence W. Lytton</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Laurence W. Lytton</signature>
        <title>Reporting person</title>
        <date>08/17/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Lytton-Kambara Foundation</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Laurence W. Lytton</signature>
        <title>President</title>
        <date>08/17/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
