X0202 SCHEDULE 13G/A 0000935836-26-000107 0001105806 XXXXXXXX LIVE 2 Common Stock 03/31/2026 0001427925 TALPHERA, INC. 00444T209 1850 GATEWAY DRIVE SUITE 175 SAN MATEO CA 94404 Rule 13d-1(c) LYTTON LAURENCE W X1 0.00 1246444.00 0.00 1246444.00 1246444.00 N 2.5 IN Percentage calculated based on 50,049,824 shares of Common Stock outstanding on March 18, 2026, as reported in the Form 10-K filed by the Issuer for the fiscal year ended December 31, 2025. LYTTON-KAMBARA FOUNDATION X1 0.00 1246444.00 0.00 1246444.00 1246444.00 N 2.5 IN : Percentage calculated based on 50,049,824 shares of Common Stock outstanding on March 18, 2026, as reported in the Form 10-K filed by the Issuer for the fiscal year ended December 31, 2025. TALPHERA, INC. 1850 Gateway Drive, Suite 175, San Mateo, CA 94404 Laurence W. Lytton and Lytton-Kambara Foundation ("Foundation"). 467 CENTRAL PARK WEST, NEW YORK, NY 10025 United States Y Lytton: 1,246,444 Foundation: 1,246,444 Lytton: 2.5% Foundation: 2.5% Lytton: 0 Foundation: 0 Lytton: 1,246,444 Foundation: 1,246,444 Lytton: 0 Foundation: 0 Lytton: 1,246,444 Foundation: 1,246,444 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. EXHIBIT 99.1 - AGREEMENT REGARDING JOINT FILING OF STATEMENT ON SCHEDULE 13D OR 13G LYTTON LAURENCE W /s/ Laurence W. Lytton 05/15/2026 LYTTON-KAMBARA FOUNDATION /s/ Laurence W. Lytton 05/15/2026