144 0001796960 XXXXXXXX LIVE 0001104506 INSMED INC 000-30739 700 US Highway 202/206 Bridgewater NJ 08807 9089779900 Martina Flammer Officer Common Merrill Lynch

1800 K ST NW Suite 800 Washington DC 20006

5138 894885 213273469 01/08/2026 NASDAQ Common 01/04/2026 Stock Plan Activity Issuer N 1603 01/04/2026 n/a Common 01/05/2026 Stock Plan Activity Issuer N 1648 01/05/2026 n/a Common 01/06/2026 Stock Plan Activity Issuer N 1887 01/06/2026 n/a N Martina Flammer

700 US Highway 202/206 Bridgewater NJ 08807

Common 01/07/2026 1434 252154 Martina Flammer

700 US Highway 202/206 Bridgewater NJ 08807

Common 01/06/2026 10185 1770153 Martina Flammer

700 US Highway 202/206 Bridgewater NJ 08807

Common 01/05/2026 12303 2108459 Martina Flammer

700 US Highway 202/206 Bridgewater NJ 08807

Common 12/01/2025 8895 1840841 Martina Flammer

700 US Highway 202/206 Bridgewater NJ 08807

Common 11/11/2025 31226 5921820 01/08/2026 02/27/2025 Martina Flammer