X0306 4 2021-01-12 0001104506 INSMED Inc INSM 0001182633 SHAROKY MELVIN MD 700 US HIGHWAY 202/206 BRIDGEWATER NJ 08807 true Common Stock 2021-01-12 5 G 0 2541 0 D 230349 D Common Stock 2021-01-21 5 G 0 847 0 D 229502 D Common Stock 2021-01-21 5 G 0 847 0 A 847 I By spouse Common Stock 2021-01-21 5 G 0 184 0 D 229318 D Common Stock 2021-01-21 5 G 0 184 0 A 184 I By Melvin Sharoky C/F Sophie C. Wink UTMA/FL Common Stock 5900 I Held by Baby Gator LLC Common Stock 7714 I Held by The Sharoky Family Foundation, Inc. Common Stock 2021-05-12 4 A 0 7558 A 236876 D The reported transactions involved a gift of securities by the Reporting Person to his spouse. The reported transactions involved a gift of securities by the Reporting Person to an investment account, Melvin Sharoky C/F Sophie C. Wink UTMA/FL, for the benefit of the Reporting Person's granddaughter. The Reporting Person is the custodian of Melvin Sharoky C/F Sophie C. Wink UTMA/FL. The Reporting Person is a managing member of Baby Gator LLC. The Reporting Person is Chairman of The Sharoky Family Foundation, Inc. and is one of three individuals who currently share voting and investment power over the shares held by The Sharoky Family Foundation, Inc. The Reporting Person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date. Each Restricted Stock Unit was granted on May 12, 2021 for no consideration. /s/ Melvin Sharoky, M.D, by Christine Pellizzari as Attorney-in-fact 2021-05-14