X0306 4 2021-03-09 0001104506 INSMED Inc INSM 0001740947 SORIANO JOHN 700 US HIGHWAY 202/206 BRIDGEWATER NJ 08807 true Chief Compliance Officer Common Stock 2021-03-09 4 M 0 13433 30.86 A 43206 D Common Stock 2021-03-09 4 S 0 13433 40.38 D 29773 D Common Stock 2021-03-09 4 M 0 17349 13.91 A 47122 D Common Stock 2021-03-09 4 S 0 17349 40.38 D 29773 D Common Stock 2021-03-09 4 M 0 14130 23.75 A 43903 D Common Stock 2021-03-09 4 S 0 14130 40.38 D 29773 D Common Stock 2021-03-10 4 M 0 500 30.86 A 30273 D Common Stock 2021-03-10 4 S 0 500 40 D 29773 D Stock Option (right to buy) 30.86 2021-03-09 4 M 0 13433 0 D 2028-01-22 Common Stock 13433 36767 D Stock Option (right to buy) 13.91 2021-03-09 4 M 0 17349 0 D 2029-01-03 Common Stock 17349 69395 D Stock Option (right to buy) 23.75 2021-03-09 4 M 0 14130 0 D 2030-01-03 Common Stock 14130 42390 D Stock Option (right to buy) 30.86 2021-03-10 4 M 0 500 0 D 2028-01-22 Common Stock 500 36267 D This is the weighted average sales price representing the shares sold at prices ranging from $40.00 to $40.61 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing the shares sold at prices ranging from $40.00 to $40.01 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. The options become exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. /s/ John Soriano, by Christine Pellizzari as Attorney-in-fact 2021-03-11