X0304 4 2012-02-28 0 0001103390 Ardea Biosciences, Inc./DE RDEA 0001202094 MANHARD KIMBERLY 4939 DIRECTORS PLACE SAN DIEGO CA 92121 0 1 0 0 SVP, Regulatory & Dev Ops Common Stock 2012-02-28 4 M 0 5000 3.90 A 14731 D Common Stock 2012-02-28 4 S 0 5000 20.9941 D 9731 D Employee Stock Option (Right to Buy) 3.90 2012-02-28 4 M 0 5000 0.00 D 2016-12-20 Common Stock 5000 20000 D The stock option exercise and sale of common stock reported in this Form 4 was effected pursuant to a Rule 10b5-1 plan dated as of June 22, 2011. The range of sales prices received was $20.46 to $21.39. Upon request by the SEC staff, the issuer, or any security holder of the issuer, full information will be provided regarding the number of shares purchased or sold at each separate price. 25% of the shares subject to the stock option vested and became exercisable on December 21, 2007. The remaining shares vest in equal monthly installments over the following 3 years. /s/ Kimberly J. Manhard 2012-02-29