X0303 4 2009-05-20 0 0001103390 Ardea Biosciences, Inc./DE RDEA 0001197360 REMINGTON JACK 4939 DIRECTORS PLACE SAN DIEGO CA 92121 1 0 0 0 Common Stock 2009-05-20 4 M 0 10000 4.08 A 11000 D Common Stock 2009-05-20 4 M 0 12500 4.36 A 23500 D Common Stock 2009-05-20 4 M 0 2500 5.85 A 26000 D Common Stock 2009-05-20 4 M 0 1250 5.85 A 27250 D Common Stock 2009-05-20 4 M 0 1250 5.85 A 28500 D Common Stock 2009-05-20 4 S 0 27500 14.9471 D 1000 D Stock Option (Right to Buy) 4.08 2009-05-20 4 M 0 10000 0.00 D 2015-01-02 Common Stock 10000 0 D Stock Option (Right to Buy) 4.36 2009-05-20 4 M 0 12500 0.00 D 2017-01-02 Common Stock 12500 0 D Stock Option (Right to Buy) 5.85 2009-05-20 4 M 0 2500 0.00 D 2017-06-14 Common Stock 2500 0 D Stock Option (Right to Buy) 5.85 2009-05-20 4 M 0 1250 0.00 D 2017-06-14 Common Stock 1250 0 D Stock Option (Right to Buy) 5.85 2009-05-20 4 M 0 1250 0.00 D 2017-06-14 Common Stock 1250 0 D Immediately exercisable, subject to a right of repurchase on behalf of the Issuer that lapsed one year from the grant date. Immediately exercisable, subject to a right of repurchase on behalf of the Issuer that lapsed on January 2, 2008. /s/ Jack S. Remington 2009-05-21