X0303 4 2009-05-20 0 0001103390 Ardea Biosciences, Inc./DE RDEA 0001292404 Beck John W 4939 DIRECTORS PLACE SAN DIEGO CA 92121 0 1 0 0 SVP, Finance & Operations, CFO Common Stock 2009-05-20 4 M 0 5000 5.85 A 5885 D Common Stock 2009-05-20 4 S 0 5000 14.9734 D 885 D Employee Stock Option (Right to Buy) 5.85 2009-05-20 4 M 0 5000 0.00 D 2017-06-14 Common Stock 5000 0 D Includes 885 shares acquired under the Ardea Biosciences, Inc. 2000 Employee Stock Purchase Plan on May 14, 2009. Immediately exercisable, subject to a right of repurchase on behalf of the Issuer that lapsed on January 2, 2008. /s/ John W. Beck 2009-05-21