License and Development Agreements - Meda License, Development and Supply Agreements - Additional Information (Detail) - USD ($)	1 Months Ended		12 Months Ended
	Nov. 30, 2015	Oct. 31, 2009	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenue Recognition, Milestone Method [Line Items]
Patent expiration year			2020
Aggregate milestones and services revenue recognized	$ 20,000,000
Contract revenues			$ 2,500,000	$ 41,759,000	$ 22,749,000
U.S. [Member]
Revenue Recognition, Milestone Method [Line Items]
Aggregate milestones and services revenue recognized		$ 59,700,000
Contract revenues			$ 0
U.S. [Member] | Milestones [Member]
Revenue Recognition, Milestone Method [Line Items]
Contract revenues				$ 1,000,000