Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues:
Product sales	$ 8,266	$ 4,157	$ 76
Product royalty revenues	3,646	1,406	3,407
Research and development reimbursements	1,134	909	12,712
Contract revenue	2,500	41,759	22,749
Total revenues	15,546	48,231	38,944
Cost of sales	11,258	8,101	4,939
Expenses:
Research and development	18,878	20,624	34,285
Selling, general and administrative	49,345	54,685	38,460
Total expenses	68,223	75,309	72,745
Loss from operations	(63,935)	(35,179)	(38,740)
Interest expense, net	(3,267)	(2,518)	(2,016)
Derivative loss			(13,167)
Other income (expense), net	64	25	(295)
Net loss	$ (67,138)	$ (37,672)	$ (54,218)
Basic and diluted loss per share	$ (1.25)	$ (0.72)	$ (1.12)
Weighted average common stock shares outstanding, basic and diluted	53,679,134	52,384,876	48,355,200