License and Development Agreements - Meda License, Development and Supply Agreements - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended		6 Months Ended
	Nov. 30, 2015	Oct. 31, 2009	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenue Recognition, Milestone Method [Line Items]
Patent expiration year					2020
Aggregate milestones and services revenue recognized	$ 20,000,000
Contract revenues			$ 2,500,000	$ 351,000	$ 2,500,000	$ 11,759,000
U.S. [Member]
Revenue Recognition, Milestone Method [Line Items]
Aggregate milestones and services revenue recognized		$ 59,700,000
Contract revenues					$ 0
U.S. [Member] | Milestones [Member]
Revenue Recognition, Milestone Method [Line Items]
Contract revenues						$ 1,000,000