License and Development Agreements - Meda License, Development and Supply Agreements - Additional Information (Detail) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended
	Nov. 30, 2015	Oct. 31, 2009	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue Recognition, Milestone Method [Line Items]
Patent expiration year			2020
Aggregate milestones and services revenue recognized	$ 20,000
Contract revenues			$ 41,759	$ 22,749	$ 6,800
U.S. [Member]
Revenue Recognition, Milestone Method [Line Items]
Aggregate milestones and services revenue recognized		$ 59,700
Contract revenues				$ 200	$ 200
U.S. [Member] | Milestones [Member]
Revenue Recognition, Milestone Method [Line Items]
Contract revenues			$ 1,000