Consolidated Statements of Stockholders' (Deficit) Equity (USD $)	Total	CDC Warrant [Member]	Private Placement [Member]	Common Stock [Member]	Common Stock [Member] CDC Warrant [Member]	Common Stock [Member] Private Placement [Member]	Additional Paid-In Capital [Member]	Additional Paid-In Capital [Member] CDC Warrant [Member]	Additional Paid-In Capital [Member] Private Placement [Member]	Treasury Stock [Member]	Accumulated Deficit [Member]	Series A Preferred Stock [Member]	Series A Preferred Stock [Member] Private Placement [Member]
Beginning Balance at Dec. 31, 2010	$ 9,786,330			$ 24,039			$ 82,055,934			$ (47,183)	$ (72,246,460)
Beginning Balance, shares at Dec. 31, 2010				24,038,445
Stock-based compensation	1,226,724						1,226,724
Stock option exercise	349,676			130			349,546
Stock option exercise, shares	129,888			129,888
CDC warrant derivative reclassified to equity	336,747						336,747
Warrant exercises		1,749,259			601			1,748,658
Warrants exercises, shares					601,120
Stock offering, net			13,996,773			4,808			13,991,965
Stock offering, net shares						4,807,693
Net income (loss)	(23,325,116)										(23,325,116)
Ending Balance at Dec. 31, 2011	4,120,393			29,578			99,709,574			(47,183)	(95,571,576)
Ending Balance, shares at Dec. 31, 2011				29,577,146
Stock-based compensation	1,619,269						1,619,269
Stock option exercise	2,054,100			789			2,053,311
Stock option exercise, shares	789,305			789,305
Restricted stock awards				58			(58)
Restricted stock awards, shares				57,500
Warrant derivative liability reclassified to equity	1,037,237						1,037,237
Warrant exercises	921,019			282			920,737
Warrants exercises, shares				281,865
Stock offering, net			38,373,014			6,792			38,363,513				2,709
Stock offering, net shares				6,791,887		6,791,887							2,709,300
Net income (loss)	1,652,181										1,652,181
Ending Balance at Dec. 31, 2012	49,777,213			37,499			143,703,583			(47,183)	(93,919,395)	2,709
Ending Balance, shares at Dec. 31, 2012				37,497,703								2,709,300
Stock-based compensation	3,327,014						3,327,014
Stock option exercise	357,281			115			357,166
Stock option exercise, shares	115,667			115,667
Restricted stock awards				80			(80)
Restricted stock awards, shares				80,498
Warrant derivative liability reclassified to equity	11,266						11,266
Warrant exercises	50,000			10			49,990
Warrants exercises, shares				10,000
Shares issued to Arcion in acquisition of research and development license	2,072,136			500			2,071,636
Shares issued to Arcion in acquisition of research and development license , shares				500,516
Warrants issued in connection with notes payable	986,352						986,352
Net income (loss)	(57,393,613)										(57,393,613)
Ending Balance at Dec. 31, 2013	$ (812,351)			$ 38,204			$ 150,506,927			$ (47,183)	$ (151,313,008)	$ 2,709
Ending Balance, shares at Dec. 31, 2013				38,204,384								2,709,300