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&lt;tr&gt;
&lt;td valign="top" width="4%" align="left"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;12.&lt;/b&gt;&lt;/font&gt;&lt;/td&gt;
&lt;td valign="top" align="left"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Subsequent
event:&lt;/b&gt;&lt;/font&gt;&lt;/td&gt;
&lt;/tr&gt;
&lt;/table&gt;
&lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;i&gt;Midcap:&lt;/i&gt;&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;On July&amp;#xA0;5, 2013, the
Company, Arius One and Arius Two (the &amp;#x201C;Borrowers&amp;#x201D;)
entered into a $20 million secured loan facility (the &amp;#x201C;Loan
Transaction&amp;#x201D; and such loan, the &amp;#x201C;Loan&amp;#x201D;) with
MidCap as agent and lender pursuant to the terms and conditions of
the Credit Agreement. The Company received net proceeds in the
aggregate amount of $19.9 million and will use the Loan proceeds
for general corporate purposes or other activities of the Borrower
permitted under the Credit Agreement.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;In addition, pursuant to
the Loan Transaction, the Company issued to MidCap a warrant (the
&amp;#x201C;MidCap Warrant&amp;#x201D;) to purchase 357,356 unregistered
shares of Common Stock, which warrant has an exercise price of
$4.20 per share, the 20-day volume-weighted average share price of
the Common Stock prior to the closing of the Loan. The MidCap
Warrant is exercisable for a term of five (5)&amp;#xA0;years and
contains cashless exercise provisions and customary, stock-based
anti-dilution protection provisions.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Loan has a term of 36
months with interest only payments for the first 6 months. The
interest rate is 8.45% plus a LIBOR floor of 0.5%. Upon execution
of the Credit Agreement, the Company paid to MidCap a closing fee
of 0.5% of the aggregate Loan amount. Upon repayment in full of the
Loan, the Company is obligated to make a final&amp;#xA0;payment fee
equal to 3.5% of the aggregate Loan amount. In addition, the
Company may prepay all or any portion of the Loan at any time
subject to a prepayment premium of: (i)&amp;#xA0;5% of the Loan amount
prepaid in the first year of the Loan and (ii)&amp;#xA0;3% of the Loan
amount prepaid in each year thereafter. In addition, if the Company
receives the second of two anticipated database lock milestone
payments (the &amp;#x201C;Database Lock Payments&amp;#x201D;) from Endo in
connection with the Endo Agreement, the Company may prepay 50% of
the principal amount of the Loan then outstanding and, concurrently
and at the Company&amp;#x2019;s election, either: (i)&amp;#xA0;pay to MidCap
a cash prepayment fee of 2% of the principal amount of the Loan and
all obligations thereunder outstanding as of the date of prepayment
or (ii)&amp;#xA0;issue to MidCap a warrant (in a form substantially
similar to the MidCap Warrant) to purchase shares of Common Stock
equal to 2.0% of the prepayment amount, with the number of shares
being calculated using the Black-Scholes pricing model.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The obligations of the
Borrowers under the Credit Agreement are secured by a first
priority lien in favor of MidCap on substantially all of the
Borrowers&amp;#x2019; existing and after-acquired assets, but excluding
certain of the Borrowers&amp;#x2019; intellectual property and general
intangible assets of the Borrowers (but not any proceeds thereof).
The obligations of the Company under the Loan Agreement are also
secured by a first priority lien on the equity interests held by
the Company in Arius One, Arius Two and BND. The Borrowers entered
into customary pledge and intellectual property security agreements
to evidence the security interest in favor of MidCap.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;Under the Credit Agreement,
the Borrowers are subject to affirmative covenants which are
customary for financings of this&amp;#xA0;type, including the
obligations of the Borrowers to: (i)&amp;#xA0;maintain good standing
and governmental authorizations, (ii)&amp;#xA0;provide certain
information and notices to MidCap, (iii)&amp;#xA0;deliver monthly and
annual financial statements to MidCap, (iv)&amp;#xA0;maintain
insurance, (v)&amp;#xA0;discharge all taxes, (vi)&amp;#xA0;protect their
intellectual property and (vii)&amp;#xA0;generally protect the
collateral granted to MidCap.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px; FONT-SIZE: 1px"&gt;
&amp;#xA0;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Borrowers are also
subject to negative covenants customary for financings of this
type, including that they may not: (i)&amp;#xA0;enter into a merger or
consolidation or certain change of control events, (ii)&amp;#xA0;incur
liens on the collateral, (iii)&amp;#xA0;incur additional indebtedness,
(iii)&amp;#xA0;dispose of any property, (iv)&amp;#xA0;amend material
agreements or organizational documents, (v)&amp;#xA0;change their
jurisdictions of organization or their organizational structures or
types, (vi)&amp;#xA0;declare or pay dividends (other than dividends
payable solely in Common Stock), (vii)&amp;#xA0;make certain
investments or acquisitions, or (viii)&amp;#xA0;enter into certain
transactions with affiliates, in each case subject to certain
exceptions provided for in the Credit Agreement, including
exceptions that allow the Borrowers to acquire additional products
and to enter into licenses and similar agreements provided certain
conditions are met.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Credit Agreement
provides that events of default include: (i)&amp;#xA0;failure to make
payment&amp;#xA0;of principal or interest on the Loan when required,
(ii)&amp;#xA0;failure to perform obligations under the Credit Agreement
and related&amp;#xA0;documents, (iii)&amp;#xA0;defaults in other
indebtedness and breaches of material agreements of the Borrowers,
(iv)&amp;#xA0;if any Borrower shall generally not pay its debts as such
debts become due and similar insolvency matters, (v)&amp;#xA0;material
adverse changes to the Borrowers (subject to a 10-day notice and
cure period), (vi)&amp;#xA0;if the Company ceases to be a
publicly-listed and reporting company, (vii)&amp;#xA0;failure to
receive the Database Lock Payments by June&amp;#xA0;30, 2014, and
(viii)&amp;#xA0;certain other events, including certain adverse actions
taken by the Food and Drug Administration or other governmental
authorities. Upon an event of default, the Borrower&amp;#x2019;s
obligations under the Credit Agreement may, or in the event of
insolvency or bankruptcy will automatically, be accelerated. Upon
the&amp;#xA0;occurrence of any event of default, the Borrower&amp;#x2019;s
obligations under the Credit Agreement will bear interest at a rate
equal to the lesser of: (i)&amp;#xA0;4% above the rate of interest
applicable to such obligations immediately prior to the occurrence
of the event of default and&amp;#xA0;(ii) the maximum rate allowable
under law.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 18px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;i&gt;TTY
Biopharm:&lt;/i&gt;&lt;/font&gt;&lt;/p&gt;
&lt;p style="PADDING-BOTTOM: 0px; MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;On
July&amp;#xA0;29, 2013, the Company announced the regulatory approval
of ONSOLIS&lt;font style="FONT-FAMILY: Times New Roman" size="1"&gt;&lt;sup style="POSITION: relative; BOTTOM: 0.8ex; VERTICAL-ALIGN: baseline"&gt;&amp;#xAE;&lt;/sup&gt;&lt;/font&gt;
in Taiwan for the management of breakthrough cancer pain in opioid
tolerant, adult patients with cancer.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;In Taiwan, the Company has
licensed the commercialization rights to TTY, where the product
will be marketed under the brand name PAINKYL&amp;#x2122;. TTY will be
responsible for the cost of future product commercialization in
Taiwan and expects to launch PAINKYL&amp;#x2122; following receipt of
reimbursement pricing from the Taiwanese national healthcare
system. The approval in Taiwan results in a milestone payment of
$0.3 million to the Company, which is expected to be received in
the third quarter 2013. Upon launch, the Company will receive a
royalty on net sales.&lt;/font&gt;&lt;/p&gt;
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