X0202 5 2007-12-31 0 0 0 0001103021 BIODELIVERY SCIENCES INTERNATIONAL INC BDSI 0001196697 MANNINO RAPHAEL J 185 SOUTH ORANGE AVENUE NEWARK NJ 01703 1 1 0 0 Executive VP & CSO Common Stock 212609 D Stock Option (right to buy) 2.42 2007-01-26 5 L 0 32558 A 2017-01-26 Common Stock 32558 32558 D Stock Option 2.42 2007-01-26 5 L 0 14299 A 2017-01-26 Common Stock 14299 14299 D Stock Option 3.83 2003-08-14 2013-08-14 Common Stock 51449 51449 D Stock Option 2.29 2004-07-29 2014-07-29 Common Stock 20000 20000 D Stock Option 2.05 2006-07-27 2016-07-27 Common Stock 20000 20000 D Stock Option 2.05 2016-07-27 Common Stock 14894 14894 D Stock Option 2.94 2006-07-28 2016-07-28 Common Stock 20000 20000 D Stock Option 2.94 2016-07-28 Common Stock 10714 10714 D Stock Option 3.4 2006-10-21 2016-10-21 Common Stock 6176 6176 D Stock Option 4.13 2007-07-25 2017-07-25 Common Stock 20000 20000 D 21,704 of these stock options have vested and are exercisable, whereas the remainder of such options has not yet vested, subject to the continued employment of the reporting person. Not applicable. Granted by the Board of Directors of the Company. None of these stock options have vested and the vesting of such options is subject to the continued employment of the reporting person. 4,964 of these stock options have vested and are exercisable, whereas the remainder of such options has not yet vested, subject to the continued employment of the reporting person. 7,142 of these stock options have vested and are exercisable, whereas the remainder of such options has not yet vested, subject to the continued employment of the reporting person. /s/ Raphael J. Mannino 2008-02-13