X0202 4 2007-07-27 0 0001103021 BIODELIVERY SCIENCES INTERNATIONAL INC BDSI 0001196697 MANNINO RAPHAEL J 185 SOUTH ORANGE AVENUE NEWARK NJ 01703 1 1 0 0 Executive VP & CSO Common Stock 152609 D Option 5.50 2002-03-06 2007-09-26 Common Stock 15423 15423 D Option 1.63 2003-01-31 2008-01-31 Common Stock 60000 60000 D Option 3.83 2003-08-14 2013-08-14 Common Stock 51449 51449 D Option 2.29 2004-07-29 2014-07-29 Common Stock 20000 20000 D Option 2.05 2007-07-27 4 A 0 4964 0 A 2006-07-27 2016-07-27 Common Stock 20000 24964 D Option 2.94 2007-07-28 4 A 0 3571 0 A 2006-07-28 2015-07-28 Common Stock 23571 27142 D Option 3.40 2006-10-21 2014-10-21 Common Stock 4117 4117 D Stock options being reported by this line item are being exercised at $1.70 per share; no disposition of common stock underlying such options has been made. /s/ Raphael J. Mannino 2007-07-31