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Notes Payable - Additional Information (Detail) - USD ($)
$ in Thousands
12 Months Ended
Sep. 23, 2021
May 23, 2019
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Debt Instrument [Line Items]          
Notes payable repayments     $ 20,000 $ 0 $ 67,346
Bio Pharma Credit Plc          
Debt Instrument [Line Items]          
Maximum borrowing capacity   $ 60,000      
Additional facility that can be obtained   20,000      
Debt instrument, face amount   60,000      
Additional borrowing of face amount   1,800      
Loan agreement term (in months)     72 months    
Loan agreement interest only term (in months)     36 months    
Notes payable repayments $ 20,000        
Accrued interest $ 1,500        
Bio Pharma Credit Plc | LIBOR          
Debt Instrument [Line Items]          
Additional interest rate (percentage)     7.50%    
Bio Pharma Credit Plc | LIBOR | Minimum          
Debt Instrument [Line Items]          
Additional interest rate (percentage)     2.00%    
CRG          
Debt Instrument [Line Items]          
Back end facility fee   $ 5,600      
CRG | Interest Expense          
Debt Instrument [Line Items]          
Debt issuance costs         5,200
Amortization of discount         3,900
Loan preclosure fees         $ 2,800