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License Agreements and Acquired Product Rights - Additional Information (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Aug. 03, 2021
Apr. 04, 2019
Jun. 30, 2019
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Oct. 04, 2019
Finite-Lived Intangible Assets [Line Items]              
Selling, general and administrative       $ 106,206 $ 98,827 $ 86,063  
ELYXYB product rights              
Finite-Lived Intangible Assets [Line Items]              
Up-front payment $ 6,000            
Price of acquisition 9,000            
Additional payment 9,000            
Total milestone payments 262,000            
Minimum | ELYXYB product rights              
Finite-Lived Intangible Assets [Line Items]              
Milestone payment, net sales 4,000            
Milestone payment requirement, net sales 50,000            
Maximum | ELYXYB product rights              
Finite-Lived Intangible Assets [Line Items]              
Milestone payment, net sales 100,000            
Milestone payment requirement, net sales $ 1,000,000            
Shiongi License And Supply Agreement              
Finite-Lived Intangible Assets [Line Items]              
Term of contract (in years)       2 years      
Symproic license and distribution rights | Shiongi License And Supply Agreement              
Finite-Lived Intangible Assets [Line Items]              
Upfront first installment payment   $ 20,000          
Upfront installment hence to be made             $ 10,000
Selling, general and administrative           $ 400  
Symproic license and distribution rights | Shiongi License And Supply Agreement | Additional Royalty As A Percentage | Product Concentration Risk | Revenue              
Finite-Lived Intangible Assets [Line Items]              
Concentration risk percentage     1.00%        
Symproic license and distribution rights | Shiongi License And Supply Agreement | Royalty Agreement Terms | Minimum | Product Concentration Risk | Revenue              
Finite-Lived Intangible Assets [Line Items]              
Concentration risk percentage   8.50%          
Symproic license and distribution rights | Shiongi License And Supply Agreement | Royalty Agreement Terms | Maximum | Product Concentration Risk | Revenue              
Finite-Lived Intangible Assets [Line Items]              
Concentration risk percentage     17.50%