Delaware Page 1 The First State I, JEFFREY W. BULLOCK, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED ARE TRUE AND CORRECT COPIES OF ALL DOCUMENTS ON FILE OF “BIODELIVERY SCIENCES INTERNATIONAL, INC.” AS RECEIVED AND FILED IN THIS OFFICE. THE FOLLOWING DOCUMENTS HAVE BEEN CERTIFIED: CERTIFICATE OF INCORPORATION, FILED THE EIGHTEENTH DAY OF APRIL, A.D. 2002, AT 9 O`CLOCK A.M. CERTIFICATE OF OWNERSHIP, FILED THE THIRD DAY OF JUNE, A.D. 2002, AT 9 O`CLOCK A.M. CERTIFICATE OF DESIGNATION, FILED THE TWENTIETH DAY OF AUGUST, A.D. 2004, AT 5 O`CLOCK P.M. CERTIFICATE OF CORRECTION, FILED THE TWENTY-FIFTH DAY OF AUGUST, A.D. 2004, AT 3:10 O`CLOCK P.M. CERTIFICATE OF CORRECTION, FILED THE SECOND DAY OF SEPTEMBER, A.D. 2004, AT 9:27 O`CLOCK A.M. CERTIFICATE OF DESIGNATION, FILED THE THIRD DAY OF SEPTEMBER, A.D. 2004, AT 5:18 O`CLOCK P.M. 3515699 8100H Authentication: 203368507 SR# 20206471278 Date: 07-29-20 You may verify this certificate online at corp.delaware.gov/authver.shtml

Delaware Page 2 The First State CERTIFICATE OF DESIGNATION, FILED THE TWENTY-SECOND DAY OF FEBRUARY, A.D. 2007, AT 4:43 O`CLOCK P.M. CERTIFICATE OF AMENDMENT, FILED THE TWENTY-FIFTH DAY OF JULY, A.D. 2008, AT 12 O`CLOCK P.M. CERTIFICATE OF DESIGNATION, FILED THE TWELFTH DAY OF FEBRUARY, A.D. 2009, AT 2:44 O`CLOCK P.M. CERTIFICATE OF AMENDMENT, FILED THE TWENTY-SECOND DAY OF JULY, A.D. 2011, AT 3:25 O`CLOCK P.M. CERTIFICATE OF DESIGNATION, FILED THE THIRTIETH DAY OF NOVEMBER, A.D. 2012, AT 1:11 O`CLOCK P.M. CERTIFICATE OF DESIGNATION, FILED THE TWENTY-FIRST DAY OF MAY, A.D. 2018, AT 9:59 O`CLOCK A.M. CERTIFICATE OF AMENDMENT, FILED THE SIXTH DAY OF AUGUST, A.D. 2018, AT 4:24 O`CLOCK P.M. CERTIFICATE OF AMENDMENT, FILED THE TWENTY-FIFTH DAY OF JULY, A.D. 2019, AT 2:33 O`CLOCK P.M. CERTIFICATE OF AMENDMENT, FILED THE TWENTY-THIRD DAY OF JULY, A.D. 2020, AT 3:14 O`CLOCK P.M. 3515699 8100H Authentication: 203368507 SR# 20206471278 Date: 07-29-20 You may verify this certificate online at corp.delaware.gov/authver.shtml

Delaware Page 3 The First State AND I DO HEREBY FURTHER CERTIFY THAT THE AFORESAID CERTIFICATES ARE THE ONLY CERTIFICATES ON RECORD OF THE AFORESAID CORPORATION, “BIODELIVERY SCIENCES INTERNATIONAL, INC.”. 3515699 8100H Authentication: 203368507 SR# 20206471278 Date: 07-29-20 You may verify this certificate online at corp.delaware.gov/authver.shtml